Glutathione and Detoxification

Medical science and public health measures have notably reduced death rates and prolonged the average life span, especially in developed countries. But development has its downside. Our environment contains tens of thou-sands of confirmed toxic substances, and the pace of life and consumer-oriented marketing promote bad lifestyle habits which we all adopt to some extent. We in the twentieth-century can expect a longer life span than our ancestors, but one potentially burdened by chronic ailments. The full promise of longevity is blunted.

What's remarkable is that we don't succumb even earlier to the daily onslaught of toxins in our food, air and water. We have our body's defense mechanisms to thank, notably the GSH detoxification process. But like all biological systems, even this can be overwhelmed by extensive or prolonged attack and may eventually begin to function poorly.

Although GSH was discovered in 1888 by De-Rey-Pailhade, it was not until the 1970's that its detoxifying role was recognized. Over the past thirty years scientific understanding of this process has unfolded slowly, but the huge resurgence of interest in preventive medicine and in GSH is giving rise to new discoveries. The liver and the kidney are the major organs of detoxification and elimination and have the highest levels of intracellular GSH in the body (see figure 7). GSH is the most important thiol (sulfur-containing amino-acid) in living systems. It plays a critical role not only in humans and mammals, but in all vertebrates and even in insects, plants and micro-organisms.

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